Itchy Skin No Rash Cancer, Worse at Night, Stress, Liver Disease, Causes, Food Allergy, Hay Fever, At Night

Have you ever experienced an itchy skin with no rash? Here, in this article, we keenly look at the itchy skin due to cancer, worse at night, liver disease, food allergy and hay fever.

Itchy Skin No Rash Cancer

Itchy skin has several causes, which includes dryness and allergies, but rarely does it signal that an individual has cancer.

This symptom might happen due to complications of the disease, itchy skin and rashes are also a common side effect of some of the cancer drugs. Most skin of the cancers, like malignant melanoma, don’t normally lead to any itching.

Itchy Skin No Rash

Itchy Skin No Rash

One form of cancer that is accompanied by itching is polycythemia vera, one of several blood cancers called myeloproliferative disorders.

People with this kind of disease can experience itchiness especially after a warm bath or even hot shower, but this is only one of several symptoms that is associated with polycythemia vera. Others include trouble when breathing while lying down, headache and others.

Scaly skin may be an indication of Sezary Syndrome, which are cutaneous T-cell lymphoma. Mycosis fungoides goes through some phases, starting with red rashes which last for several months, followed by development of bumps or hardened lesions on skin, and tumors which form on skin and can be infected.

Pancreatic cancer is a disease where patients experience itching, but itching is not an indication of pancreatic cancer. In this type of cancer, patients experience itching if the tumor blocks the bile duct and leads to jaundice. When this happens, chemicals in bile leak into skin and lead to itching.

Some of the cancer treatments might lead to itchy skin no rash over entire body or even in isolated areas. This can due to a hypersensitivity reaction that occurs during chemotherapy infusion. In some of the cases, itching can be a chronic side effect of treatments, which includes biologic agents a variety of targeted drugs.

Itchy Skin No Rash Worse at Night

Itchy skin at night, known as nocturnal pruritus, may be severe enough to disrupt your sleep regularly. Why this occurs range from natural causes to serious health concerns.

Natural causes

For many people, natural mechanisms is suspected to be behind nighttime itch. Your body’s natural circadian rhythms influence skin functions such as temperature regulation, and barrier protection. These functions can then change at night. For instance, your body temperature and blood flow to skin both increase in evening, thus warming your skin. A rise in skin temperature might also make you feel itchy.

Your body’s release of some substances varies by time of day. At night, you release extra amount of cytokines, thus increasing inflammation. Meanwhile, production of the corticosteroids — which are hormones which reduce inflammation — slows.

On top of the factors, your skin then loses a lot of water at night. During the dry winter months, your parched skin itches.

When itchiness occurs during the day, work and several other activities distract you from annoying sensation. At night there are very few distractions, which makes the itch feel more intense.

Health-related causes

Along with your body’s natural circadian rhythms, several health conditions can lead to the itchy skin to becoming worse at night. These are:

  • skin diseases like atopic dermatitis, psoriasis, and hives
  • bugs like scabies, bed bugs and pinworms
  • iron deficiency anemia
  • psychological conditions like stress and schizophrenia
  • cancers like leukemia and lymphoma
  • nerve disorders, like multiple sclerosis and diabetes
  • allergic reactions to substances such as chemicals, drugs or cosmetics

Itchy Skin No Rash Stress

Because there are several medical conditions which leads to cause anxiety and anxiety-like sensations and symptoms, which includes this one, it is recommended that all new, persistent, and also returning symptoms be reported to your doctor.

If your doctor observes that your sensations and symptoms are solely stress related, you might then be confident that there isn’t another medical reason behind their occurrence.

Generally, most of the doctors can tell the difference between stress- and anxiety-caused sensations and symptoms from those brought about by several other medical conditions.

If you are not sure about your doctor’s diagnosis, however, you may want to seek a second opinion. But if all the opinions concur, you might then be assured that stress is the cause of your sensations and symptoms and no other medical or biological problem.

If your itching and burning skin sensation is attributed to anxiety and stress, then behaving apprehensively makes the body to activate the stress response, bringing about specific physiological, and emotional changes in body so as to enhance the body’s ability to deal with a threat. Because of the nature of the changes, the stress response is usually known as the fight or flight response.

Because stress responses lead to such dramatic changes in the body, they stress the nervous system which is responsible for sending and receiving sensory information to and from brain, including sensory information from the nerve endings in skin.

A body which becomes stress-response hyperstimulated can behave in erratic ways. Experiencing itching and also burning of skin for no good reason is an example the body’s nervous system and sensory organs can ‘misbehave’ because of being overly stressed.

While anxiety and stress caused itchy skin no rash and burning skin sensations are unusual, they aren’t an indication of a serious medical problem. It’s one more way that a stress-response hyperstimulated body produces odd and erratic symptoms.

Itchy Skin No Rash Liver

Itchy skin, can happens with a several medical conditions and can be distressing. Liver diseases with bile obstruction have itching as a symptom, but the reason for the itching is not clearly indicated. Treatment requires either reversing of the bile obstruction or even medications that can used to suppress the itch.

Cholestatic Liver Disease

Your liver continuously produces bile, thus assisting in removal of the wastes and your intestines absorb dietary fat. Bile is usually produced in liver cells, travels out of bile ducts via the pancreas and finally empties into small intestine. A blockage which is anywhere along the pathway may stop the flow of bile — cholestasis — and can cause increased levels of bile in the bloodstream.

Yellowing of skin and eyes, dark urine as well as light stools usually appear as the bile levels climb, normally accompanied by the widespread itching. Bile flow obstruction can happen inside the liver — for instance, because of hepatitis, drug use or even pregnancy; or it can happen outside the liver, because of gallstones or inflammation of the pancreas.

Pruritus and Liver Disease

Widespread itching from liver disease appears before other symptoms of cholestasis develop. Itching is most severe on palms and soles of the feet, and worse in late evening and also at night. No rash or other lesions are present, except when scratching itself damages skin.

Unless liver disease is the cause of itching, your doctor will perform tests so as to confirm the diagnosis, which includes a blood bilirubin level, liver function tests and a liver ultrasound so as to look for bile duct changes.

Explanation for Cholestatic Itching

The reason for generalized itching with the liver disease is not well indicated, other than apparent link that exists with obstructed bile flow.

Bile salts, chemicals that are closely related to bile, are then deposited in skin while the bilirubin levels rise and have been said to be the primary cause of itching. Research on a protein known as autotaxin as the potential cause for Cholestatic itching, which can eventually cause new treatment options.

Detailed research as well as explanations are very difficult when a symptom like itching happens with several diseases, is experienced differently by each individual and responds to different treatments in the different cases.


Treatment of Itching With Cholestasis

Resolving the cause of bile flow obstruction has been established as the best treatment that is used for itching with liver disease, but when it isn’t possible several medications might assist to relieve the itch. Cholestyramine is used often, and works by binding bile salts in intestines so that they are excreted rather than being reabsorbed back into bloodstream.

Rifampicin, causes an increase in the liver metabolism of bile and several other chemicals, and relieves the itching in most of the people. Drugs which block opioid receptors in body also of help, indicating that your body’s own endorphins can play a crucial role in pruritus. Stopping drugs which may further harm the liver, like alcohol, is also recommended.

Itching Without Rash

With or without a rash, itchiness is a frequently reported symptom in all the skin conditions. Even when there is no rash, the other possible reasons for itchiness, are numerous and might include various illnesses and several normal conditions as wells as responses.

These leads to overlap, depending on how you look at the condition. For instance, plain old dry skin can lead to itchiness, but so are several different systemic illnesses that lead to itchy skin no rash.

Dry Skin

Dry skin is the common reason for itchiness without a rash. This is true in people who are over 65 years of age. Itchiness without a cause is common among older individuals.

Exposures and Reactions

Allergens and irritants produce itchiness with or without a rash, and sometimes itchiness might precede development of a rash on skin. Irritants like a new soap, or a new perfume are to be blamed, and irritants often cause a cycle of itchy skin no rash.

Normal processes like pregnancy are also associated with itching, as the skin which is over the expanding abdomen stretches. In addition, pregnant women sometimes develop a liver problem known as cholestasis which is associated with itching.

A very rare type of itchiness, known as aquagenic pruritus, is associated with the exposure to water of temperature. Sometimes an unexplained case of itchiness disappears and never surfaces again, while some other times, it continues and leads to diagnosis of a systemic disease.

Compounds in the Blood

Some illnesses are associated with the changes in the blood chemistry, and the compounds are said to be involved in leading to the itchiness. How and why some compounds promote itchiness is still not completely explained by the medical fraternity.

Urea is a compound which is filtered out into urine by the kidneys. When people have problems with both kidneys which are not functioning well, or renal failure, then the excessive urea is associated with the itchiness.

When a person has a blockage of bile system in liver, itch is a symptom. Itch occurs in about 100% of patients with blocked bile flow and yellow jaundice of skin and eyes. Deficiencies can also lead to itchiness: iron deficiency, with or without anemia may produce generalized itchiness.

The excess amount of hemoglobin as well as red blood cells that are seen in a condition known as polycythemia vera is also said to be a cause of itchiness – one that can appear seem at first to be because of exposure to water.

Drugs and Psychological Causes

Itching is a side effect of morphine and other opioids, and several other forms of illicit drug use are associated with itchy skin no rash. What is more is that there is a psychological component to itch, and sometimes it might be significant.

Hormones, Infections and Malignancies

Disorders of thyroid gland, and less commonly insufficient thyroid hormone levels – are said to be associated with itchiness. HIV and hepatitis C virus are also some of the infections that are linked to generalized itchiness. Lymphomas are indicated for itchiness as a potential symptom. Solid tumors like lung, colon, brain and breast cancers can also lead to itchiness

Food Allergy Itchy Skin No Rash

Foods should not lead to body itching unless there is another medical condition, like a food allergy, a pollen allergy or even histamine intolerance. If you develop any kind of itching on your body after eating some foods, then ensure that you keep a record of the foods that cause itching.

Discuss your symptoms with your doctor so as to determine the condition which is causing the itching on your body. Do not modify your diet without first consulting with your doctor. If you have a food allergy, eating of the foods that leads to itching may cause further complications.

Food Allergy

Food allergies are the most common cause of the body itching. A food allergy leads to the body creating chemicals which leads to inflammation, itching and also redness in skin. The most common foods which lead to an allergic reaction in most of the people include wheat, milk, soy, fish and tree nuts.

Other common foods which may trigger an allergy are tomatoes, pineapple and food additives. Itching from food allergies can cause hives, eczema and general skin irritation that is anywhere on body. Antihistamines are most commonly used to treat an allergic reaction.

Oral Allergy Syndrome

Oral allergy syndrome leads to itching in mouth and lips and is said to be due to cross-reactivity. Cross-reactivity happens in the body when immune system mistakes proteins that are in a certain food as if it is pollen.

The most common foods which leads to this syndrome are fruits and nuts. For example, if you’re allergic to ragweed pollen, eating zucchini, melons and cucumber can lead to itching happening in your mouth. In some cases cooking the fruit or nut will prevent itching symptoms from developing.

Histamine Intolerance

Histamine is a chemical found in the body which prevents infection. A lot of histamine will lead to inflammation, itching as well as swelling in soft tissues, like in lungs, the skin as well as the sinuses.

Certain foods have histamine and leads to a sensitivity in the body. Red wine, mackerel, cheese, eggplant and yeast all have histamine. Other symptoms include headaches, a rapid heart rate, wheezing and fainting.

Hay Fever Itchy Skin No Rash

Antihistamines assists to block an allergic reaction whether it’s on your skin or even within your body, like your nasal cavity. When you have an allergic reaction to something, you won’t always develop a skin rash accompanying the signs of an allergic reaction.

If you develop the itchy skin without a rash which does not respond well to antihistamines, then you should let your doctor know.


Antihistamines assists to reduce allergy symptoms like itchy skin no rash, sneezing and also the runny nose. They can also assist in decreasing allergic skin reactions that cause a rash, but they work even if a rash is not found.

Antihistamines are available even without a prescription, depending on strength, and can have side effects like blurry vision and drowsiness. Antihistamines are not to be used with any other medications, like antibiotics. Ask your doctor if it’s safe to take an antihistamine with other medications that you might be taking.

Itchy Skin without Rash

It’s possible to have itchy skin without experiencing a rash. Itchy skin is also called pruritus, which is an irritating skin condition leading to irresistible scratching. Doctors notes that itchy skin might have several possible causes, so it can be hard to determine the exact cause. Sometimes internal diseases may lead to itchy skin, like renal failure or even the liver disease.

Flushing, usually brought about by consuming a lot of niacin, can cause you to have itchy skin. Some allergic reactions can make you to have itching of the nose, throat, skin and other areas of your body without having a rash.

Itchy Skin at Night

Although several dermatological conditions can make you have an itchy skin no rash at night, most often the condition is because of xerosis, which is an abnormally dry skin. Xerosis is common in winter, when there is very little moisture in air.

The condition is not very serious and may be treated using moisturizers. If itchy skin at night is accompanied by a rash or scales, the cause can then be an underlying illness and treatment can be sought from a dermatologist.

Allergic Dermatitis

Allergic dermatitis, or also known as contact dermatitis, is brought about when a person comes in contact with an irritating lotion, chemicals or even jewelry. Besides leading to an itchy skin at night, the condition may be unsightly, with bumps and oozing.

Laundry detergent or even bleach that is used to wash linens can also be a source of irritant. It is also possible for a person to develop an allergy to a certain chemical, even though it has been used several times in the past.


Bedbugs are small, blood-feeding insects which mostly infest homes and hotels. Mattresses are a favorite hiding spot for such insects and their eggs. At night, the insects feed on human hosts. Even clean homes can have bedbugs, since the tiny insects move freely through walls as well as the pipes. They are known to cause an itchy skin with no rash.



  1. What Causes Itchy Skin at Night:
  2. Antihistamines & Itchy Skin With No Rash:
  3. What Kind of Foods Can Cause Body Itching:
  4. Itchy Skin & Liver Problems:
  5. Itching, Itchy, Burning Skin With No Rash Anxiety Symptoms:
  6. Itchy Skin at Night? Why It Happens and What You Can Do About It:
  7. Causes of Itching Without Rash:
  8. Is Itching a Sign of Cancer:


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